Mathematics of Sequence Evolution: Biological Models and Applications
Organized by Mathieu Blanchette (McGill), Hervé Philippe (Montréal)
09/23/2013 - 09/27/2013
Centre de recherches mathématiques
Models of evolution of biological sequences have gone a long way since Jukes and Cantor. First, it is no longer acceptable to consider that mutations of a given type occur independently and uniformIy across time and space. A large number of factors affect the rate at which mutations occur. Second, selective pressure makes that the probability of fixation of a mutation depends on the fitness of the mutated individual, which sometimes places unexpected constraints on the mutational process and induces strong dependencies between positions along the sequences.